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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP7 All Species: 31.82
Human Site: Y584 Identified Species: 50
UniProt: Q93009 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q93009 NP_003461.2 1102 128302 Y584 G H Q G N D M Y D E E K V K Y
Chimpanzee Pan troglodytes XP_510806 1102 128297 Y584 G H Q G N D M Y D E E K V K Y
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536979 1086 126326 Y568 G H Q G N D M Y D E E K V K Y
Cat Felis silvestris
Mouse Mus musculus Q6A4J8 1103 128457 Y585 G H Q G N D M Y D E E K V R Y
Rat Rattus norvegicus Q4VSI4 1103 128413 Y585 G H Q G N D M Y D E E K V R Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506396 1145 132881 Y627 G H Q G N D M Y D E E K V K Y
Chicken Gallus gallus Q6U7I1 1101 128279 Y584 G H Q G N D M Y D E E K V K Y
Frog Xenopus laevis NP_001121282 534 61718 F79 F Q F T V E R F S R L S E S V
Zebra Danio Brachydanio rerio XP_691215 1103 128646 Y585 G H Q G N D M Y D E E K V K Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VYQ8 1129 130428 F611 E Q H K R R L F D L E K V H P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q7JKC3 1135 131579 H594 A E L Y Q F V H D R L F E K S
Sea Urchin Strong. purpuratus XP_780569 1189 136707 F680 G H Q G N D L F D F D R I R F
Poplar Tree Populus trichocarpa XP_002316470 1116 130731 D586 I G K D V Y F D L V D H D K V
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84WU2 1115 130630 D587 I G K N I Y F D L V D H E K V
Baker's Yeast Sacchar. cerevisiae P50101 1230 143545 L611 F R L F A E E L N D S G L Q Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 97.7 N.A. 99 99 N.A. 92.4 95.9 46 94 N.A. 48.5 N.A. 34.4 54.5
Protein Similarity: 100 99.9 N.A. 98 N.A. 99.7 99.8 N.A. 94.7 97.9 47.4 96.8 N.A. 67.5 N.A. 52.5 69.2
P-Site Identity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 100 100 0 100 N.A. 26.6 N.A. 13.3 46.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 100 13.3 100 N.A. 40 N.A. 26.6 93.3
Percent
Protein Identity: 36.9 N.A. N.A. 36.5 29.4 N.A.
Protein Similarity: 54.3 N.A. N.A. 54.7 47.8 N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 0 N.A.
P-Site Similarity: 20 N.A. N.A. 20 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 60 0 14 74 7 20 0 7 0 0 % D
% Glu: 7 7 0 0 0 14 7 0 0 54 60 0 20 0 0 % E
% Phe: 14 0 7 7 0 7 14 20 0 7 0 7 0 0 7 % F
% Gly: 60 14 0 60 0 0 0 0 0 0 0 7 0 0 0 % G
% His: 0 60 7 0 0 0 0 7 0 0 0 14 0 7 0 % H
% Ile: 14 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % I
% Lys: 0 0 14 7 0 0 0 0 0 0 0 60 0 60 0 % K
% Leu: 0 0 14 0 0 0 14 7 14 7 14 0 7 0 0 % L
% Met: 0 0 0 0 0 0 54 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 7 60 0 0 0 7 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % P
% Gln: 0 14 60 0 7 0 0 0 0 0 0 0 0 7 7 % Q
% Arg: 0 7 0 0 7 7 7 0 0 14 0 7 0 20 0 % R
% Ser: 0 0 0 0 0 0 0 0 7 0 7 7 0 7 7 % S
% Thr: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 14 0 7 0 0 14 0 0 60 0 20 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 14 0 54 0 0 0 0 0 0 54 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _